Clinical Pharmacology, Clinical Research, Pfizer Global R&D, Tokyo Laboratories, Pfizer Japan Inc., Tokyo, Japan. Department of Drug Development Science & Clinical Evaluation, Keio University of Pharmacy, Tokyo, Japan. Clinical Pharmacology, Pfizer Inc, New York, NY, USA. Laboratory of Clinical Pharmacology, Yokohama University of Pharmacy, Kanagawa, Japan. Electronic address: k.chiba@hamayaku.ac.jp.